Subject: RE: data on anesthetics consumption
From: "Marju Sammul" <[email-masked]>
To: "Francesco Barone Adesi" <[email-masked]>
Date: Wed, 24 Jul 2024 14:16:28 +0300

Dear Francesco,

Please find the data below. No sales of nitrous oxide-combinations 
(N01AX63).

ATC code

ATC group / Active substance (rout of admin.)

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

Unit

N01AX13

Nitrous oxide(I)

0

0

0

13 900 000

14 116 000

14 266 000

13 394 000

11 490 000

10 022 000

11 116 000

10 162 000

11 170 000

11 696 000

11 122 000

ml

Best regards,

Marju

Marju Sammul

Bureau of Statistics

Department of Post-authorisation Safety

State Agency of Medicines

Estonia

[email-masked] <mailto:[email-masked]>

1 Nooruse Street

50411 Tartu

www.ravimiamet.ee <http://www.ravimiamet.ee>

From: Francesco Barone Adesi <[email-masked]>
Sent: teisipäev, 23. juuli 2024 20:21
To: Marju Sammul <[email-masked]>
Subject: Re: data on anesthetics consumption

Tähelepanu! Tegemist on väljastpoolt asutust saabunud kirjaga. Tundmatu 
saatja korral palume linke ja faile mitte avada.

Dear Marju,

Thank you very much for the quick and positive reply.

Apologies, in my previous email I forgot to ask you for information on 
nitrous oxide (N01AX13) and nitrous oxide-combinations (N01AX63). Do you 
have data on these medications as well?

Best regards

Francesco Barone-Adesi

Francesco Barone-Adesi

Associate Professor of Public Health

CRIMEDIM – Center for Research and Training in Disaster Medicine, 
Humanitarian Aid, and Global Health

Department of Translational Medicine

Università del Piemonte Orientale

Via Solaroli 17, 28100 Novara -Italy

Il giorno mar 23 lug 2024 alle ore 12:27 Marju Sammul < 
<mailto:[email-masked]> [email-masked]> ha scritto:

Dear Francesco,

Please find data 2010-2023.

The data for 2018-2022 are slightly corrected.

ATC code

ATC group / Active substance (rout of admin.)

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

Unit

N01A

ANESTHETICS, GENERAL

N01AB

Halogenated hydrocarbons

N01AB06

Isoflurane(I)

95 100

85 600

105 500

95 500

88 700

74 800

86 800

87 800

26 800

16 100

15 000

7 500

5 000

0

ml

N01AB07

Desflurane(I)

3 120

1 440

4 320

37 920

51 600

64 800

61 440

67 920

65 280

73 440

72 960

63 360

84 960

63 360

ml

N01AB08

Sevoflurane(I)

595 750

607 750

624 250

635 750

635 000

670 250

684 000

739 500

781 500

778 750

821 750

745 500

823 750

709 000

ml

N01AX10 propofol: solution (ml) and calculated quantity of active ingredient 
(g)

ATC code

ATC group / Active substance (rout of admin.)

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

Unit

N01A

ANESTHETICS, GENERAL

N01AX

Other general anesthetics

N01AX10

Propofol(P)

1 652 100

2 583 440

3 216 840

3 977 680

4 367 440

5 063 930

5 713 800

5 846 800

5 868 250

5 921 050

6 370 900

6 810 750

6 780 850

6 646 250

ml

N01AX10

Propofol(P)

16 526

25 804

33 398

40 667

45 269

52 094

59 353

62 378

64 928

66 441

72 430

90 030

87 964

86 257

g

Best regards,

Marju Sammul

Bureau of Statistics

Department of Post-authorisation Safety

State Agency of Medicines

Estonia

 <mailto:[email-masked]> [email-masked]

1 Nooruse Street

50411 Tartu

 <http://www.ravimiamet.ee> www.ravimiamet.ee

From: Francesco Barone Adesi < <mailto:[email-masked]> 
[email-masked]>
Sent: esmaspäev, 22. juuli 2024 20:24
To: Marju Sammul < <mailto:[email-masked]> 
[email-masked]>
Subject: Re: data on anesthetics consumption

Tähelepanu! Tegemist on väljastpoolt asutust saabunud kirjaga. Tundmatu 
saatja korral palume linke ja faile mitte avada.

Dear Mr. Marju Sammul,

I am contacting you again regarding the use of anesthetics in Estonia. Last 
year, you kindly sent me data on consumption of desflurane (N01AB07), 
isoflurane (N01AB06) and sevoflurane (N01AB08) in the period 2018-2022. Do 
you also have data on previous years (2010-2017) and 2023?

Furthermore, could it be possible to have data on the consumption of 
propofol (N01AX10) as well?

Thanks in advance for any help you can provide

Francesco Barone-Adesi

Francesco Barone-Adesi

Associate Professor of Public Health

CRIMEDIM – Center for Research and Training in Disaster Medicine, 
Humanitarian Aid, and Global Health

Department of Translational Medicine

Università del Piemonte Orientale

Via Solaroli 17, 28100 Novara -Italy

Il giorno ven 8 dic 2023 alle ore 09:10 Marju Sammul < 
<mailto:[email-masked]> [email-masked]> ha scritto:

Dear Francesco,

Thank you for your interest!

Please find the consumption of anesthetics N01AB:

Also you can find more information about the consumption of medicines from 
our statistical yearbooks 
<https://ra.web.tehik.ee/en/statistics/statistical-yearbooks> 
https://ra.web.tehik.ee/en/statistics/statistical-yearbooks , 
<https://www.ravimiamet.ee/statistika-ja-kokkuvotted/statistika/ravimiameti-statistika-aastaraamatud> 
https://www.ravimiamet.ee/statistika-ja-kokkuvotted/statistika/ravimiameti-statistika-aastaraamatud .

Best regards,

Marju Sammul

Bureau of Statistics

Department of Post-authorisation Safety

State Agency of Medicines

Estonia

 <mailto:[email-masked]> [email-masked]

1 Nooruse Street

50411 Tartu

 <http://www.ravimiamet.ee> www.ravimiamet.ee

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From: Francesco Barone Adesi < <mailto:[email-masked]> 
[email-masked]>
Sent: neljapäev, 7. detsember 2023 20:49
To: Ravimiamet < <mailto:[email-masked]> [email-masked]>
Subject: data on anesthetics consumption

Dear Republic of Estonia Agency of Medicines,

I am conducting research on the use of halogenated anesthetics among 
European countries. I see that information on desflurane (N01AB07), 
isoflurane (N01AB06) and sevoflurane (N01AB08) is available in the “Estonian 
Statistics on Medicine 2022” document. Is it be possible to have data on the 
consumptions of these anesthetics for the previous years as well?

Thanks in advance for any help you can provide

Francesco Barone-Adesi

Francesco Barone-Adesi

Associate Professor of Public Health

CRIMEDIM – Center for Research and Training in Disaster Medicine, 
Humanitarian Aid, and Global Health

Department of Translational Medicine

Università del Piemonte Orientale

Via Solaroli 17, 28100 Novara -Italy